Effect of sparsomycin on protein synthesis in the mouse liver.
- 1 March 1968
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 59 (3) , 854-860
- https://doi.org/10.1073/pnas.59.3.854
Abstract
Sparsomycin, a sulfur-containing antibiotic isolated from Streptomyces sparsogens, is a potent synthesis inhibitor whose action has previously been observed in KB cells, rabbit reticulocytes and Escherichia coli This study using a mouse liver cell-free system demonstrated that sparsomycin inhibits peptide bond formation by affecting the ribosomes The ribosomal site of action was not determined.This publication has 13 references indexed in Scilit:
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