Role of the Kidney and the Renin-Angiotensin System in the Response of Aldosterone Secretion to Hemorrhage

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Abstract
In summary, these data show that in hypophysectomized dogs: 1. Hemorrhage stimulates mainly aldosterone secretion. 2. Nephrectomy prevents stimulation of aldosterone secretion by hemorrhage. 3. Nephrectomy lowers basal secretion of aldosterone. 4. Crude saline extracts of dog kidneys, semipurified renin extracts of dog kidneys, and synthetic angiotensin can stimulate aldosterone secretion. These findings suggest that in hypophysectomized dogs, the kidney, via the renin-angiotensin system, is an important mechanism by which hemorrhage stimulates aldosterone secretion.