Long‐term Abnormalities in T and B Lymphocyte Function in Children following Treatment for Acute Lymphoblastic Leukaemia

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Abstract
T and B lymphocyte function as assessed by pokeweed mitogen stimulation and concanavalin A suppression was studied in 40 children with acute lymphoblastic leukemia who were in remission and off all treatment. Plasma cell and Ig production was reduced in off-treatment patients, particularly in those who had received cyclophosphamide as part of their treatment. The ability to suppress Ig production was also significantly reduced in these patients. These abnormalities were long-standing and were apparent up to 5 yr after stopping treatment with no indication of a return to normality. No clinical correlations were observed.