EPIDIDYMAL RESPONSE TO EXOGENOUS TESTOSTERONE IN RATS STERILIZED NEONATALLY BY ESTROGEN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 68  (1) , 14-21
Abstract
Male rats treated with estradiol dipropionate (250 .mu.g) by s.c. injection on day 5 of postnatal life failed to show maturation changes in the testis and epididymis at puberty. Histological examination at 60 days revealed inhibition of spermatogenesis at primary spermatocyte stage and atrophic Leydig cells. Epididymis presented infantile features, and there was a marked reduction in the secretory activity as revealed by lowered concentration of sialic acid and glycerylphosphorylcholine. Testosterone therapy (1 mg/day) for 45 days prior to autopsy at 60 days failed to induce completion of spermatogenesis but restored the structural and functional integrity of the epididymis.

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