Increased Valproate Serum Concentrations Upon Carbamazepine Cessation
- 1 October 1988
- Vol. 29 (5) , 578-581
- https://doi.org/10.1111/j.1528-1157.1988.tb03764.x
Abstract
Valproate (VPA) serum concentrations (Cp) were followed in six epileptic mentally retarded patients when carbamazepine (CBZ) was discontinued. VPA Cp significantly increased when CBZ was discontinued. A new plateau of VPA Cp was achieved 4 weeks post-CBZ discontinuation. This time factor is analogous to the autoinduction property of CBZ. Careful VPA Cp monitoring is recommended when CBZ or other enzyme inducing agents are discontinued.Keywords
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