Parental age at conception and offspring longevity
- 1 January 1997
- journal article
- review article
- Published by Cambridge University Press (CUP) in Reviews in Clinical Gerontology
- Vol. 7 (1) , 5-12
- https://doi.org/10.1017/s0959259897000026
Abstract
Current knowledge suggests that parental age has many influences on offspring. This topic has been exhaustively reviewed in Finch's monograph. The major maternal age-related changes in humans are increases in fetal aneuploidy later in reproductive life; Down's syndrome (trisomy 21); Kleinfelter's syndrome (XXY); Edward's syndrome (trisomy 18); and Patau's syndrome (trisomy 13). Despite a recent dramatic decrease in fetal death rates, advanced maternal age remains an important independent risk factor for fetal death.Keywords
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