CHANGES OF ANTI-TUMOR IMMUNITY OF HOSTS WITH MURINE MAMMARY-TUMORS REGRESSED BY LENTINAN - POTENTIATION OF ANTI-TUMOR DELAYED-HYPERSENSITIVITY REACTION
- 1 January 1982
- journal article
- research article
- Vol. 73 (5) , 790-797
Abstract
From 2 wk after s.c. inoculation of MM46 mammary carcinoma cells into C3H/He mice, lentinan caused tumor regression, irrespective of its administration schedule (i.e., various doses and times of treatment, before and after tumor inoculation). The humoral and cellular immune responses of tumor-bearing mice with or without lentinan treatment were studied kinetically. From 2 wk after tumor inoculation, antitumor antibodies (detected by macrophage-mediated or complement-dependent cytotoxicity assay) and LB (a serum protein) increased in tumor-bearing mice but the delayed-type hypersensitivity reaction against tumor (T-DHR) decreased. Lentinan restored and potentiated the T-DHR. The conditions under which lentinan is effective and the antitumor reactions responsible for tumor regression are discussed on the basis of these results.This publication has 3 references indexed in Scilit:
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