ComparativeIn Vitro Susceptibilities and Bactericidal Activities ofInvestigational Fluoroquinolone ABT-492 and Other Antimicrobial Agentsagainst Human Mycoplasmas andUreaplasmas

Abstract
We determined in vitro susceptibilities for ABT-492 and other antimicrobials against Mycoplasma pneumoniae , Mycoplasma fermentans , Mycoplasma hominis , and Ureaplasma species. ABT-492 MICs were ≤1 μg/ml, and the agent was bactericidal against selected isolates of M. pneumoniae and M. hominis. ABT-492 has potential for treatment of infections due to these microorganisms.

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