Effects of the Gelatin Plasma Substitutes Haemaccel®, Plasmagel® and Plasmion® (Geloplasma®) on Collagen-, ADP- and Adrenaline-Induced Aggregation of Human Platelets in vitro

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Abstract
The effect of some gelatin plasma substitutes (Haemaccel®, Plasmagel® and Plasmion® (Geloplasma®), which are widely used in Europe) on collagen-, ADP- and adrenaline-induced platelet aggregation in human PRP in vitro was studied under controlled conditions (pH, electrolyte composition). Haemaccel inhibited these aggregations, both in citrated as well as in heparinised PRP, whereas they were enhanced by both Plasmagel and Plasmion as compared to the appropriate control. Increasing the concentration of the inducer overcame the inhibition by Haemaccel. Haemaccel inhibited, while Plasmion enhanced 14C-serotonin release induced by collagen, ADP or adrenaline. Also in the presence of indomethacin (90 µM) Haemaccel inhibited aggregation induced by high concentrations of collagen and the primary aggregation induced by ADP and adrenaline, while Plasmion enhanced these aggregations. The inhibition by Haemaccel was not caused by binding of Ca2+ to Haemaccel.