Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph ofMycobacterium tuberculosis
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Open Access
- 1 February 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (2) , 1196-1203
- https://doi.org/10.1128/iai.73.2.1196-1203.2005
Abstract
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph ofMycobacterium tuberculosisin mice. The ΔlysAΔpanCDmutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.Keywords
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