Genetic association of two chromosome 14 genes (presenilin 1 and α1‐Antichymotrypsin) with Alzheimer's disease
- 1 September 1998
- journal article
- Published by Wiley in Annals of Neurology
- Vol. 44 (3) , 387-390
- https://doi.org/10.1002/ana.410440316
Abstract
We have investigated the association of two candidate genes on chromosome 14, presenilin 1 (PS1) and α1‐antichymotrypsin (ACT), with the risk of sporadic Alzheimer's disease (AD) by using 427 AD cases and 250 controls. The frequency of the ACT*A allele was significantly higher in cases than controls (0.550 vs 0.466). The stratification of the ACT data by PS1 genotypes showed that the risk associated with the ACT*A allele was confined to PS1*1 carriers only. The two‐site haplotype data for PS1 and ACT showed that the A1 haplotype, carrying the ACT*A and PS1*1 alleles, was more frequent in cases then controls (0.310 vs 0.251), whereas the frequency of the T2 haplotype, carrying the ACT*T and PS1*2 alleles, was lower in cases than controls (0.177 vs 0.237). These data indicate a possible synergistic effect of these two loci on the risk of AD.Keywords
This publication has 19 references indexed in Scilit:
- α-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish populationNeuroscience Letters, 1998
- Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer DiseaseJAMA, 1997
- ?1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E ?4 allele carriersAnnals of Neurology, 1997
- No association between the alpha 1‐antichymotrypsin A allele and Alzheimer's diseaseNeurology, 1997
- ?1-Antichymotrypsin gene polymorphism and risk for Alzheimer's diseaseJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1996
- No Genetic Effect of α1-Antichymotrypsin in Alzheimer DiseaseGenomics, 1996
- Molecular genetics of Alzheimer's diseaseActa Neurologica Scandinavica, 1996
- Polymorphism in AACT gene may lower age of onset of Alzheimerʼs diseaseNeuroReport, 1996
- A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphismNature Genetics, 1995
- Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndromeJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1995