Cytotoxicity and Immunosuppressive Activity of Withanolides fromDiscopodium penninervium
- 1 February 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 63 (01) , 15-17
- https://doi.org/10.1055/s-2006-957594
Abstract
The cytotoxicity and immunosuppressive activities of jaborosalactone-L and three 16α-oxygenated withanolides from the leaves of Discopodium penninervium were studied. Jaborosalactone-L showed cytotoxicity only to the murine macrophage cell line, RAW 264.7, but the 16α-oxygenated withanolides exhibited cytotoxicity to both human (COR-L23 and ECV 304) and murine (L929 and RAW 264.7) carcinoma cell lines with IC50 values ranging from 1.2-150 µM. The non-toxic concentrations of these withanolides were also found to reduce the proliferative response of both inactive and E. coli lipopolysaccharide and concanavalin A activated rat spleen cells in vitro.Keywords
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