Pharmacological Studies on Saiko-prescriptions. III. Inhibitory Effects of Saiko-prescriptions on Experimental Inflammatory Actions in Rats

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Abstract
Actions of 3 saiko-zai, daisaiko-to, shosaiko-to and saikokeishi-to, consisting of basic (BASE) and additional (A, B and C, respectively) prescriptions, were studied on the experimental models of inflammation in rats. BASE did not produce any inhibitions on paw edema induced by carrageenin, dextran and burn but had a potent action on adjuvant arthritis. A and BASE+A (daisaiko-to) inhibited paw edema induced by carrageenin and dextran as much as aspirin did and inhibited adjuvant arthritis, in which secondary stage of inflammation was suppressed more strongly than primary stage. C and BASE+C (saikokeishi-to) inhibited dextran-induced paw edema to the same extent as aminopyrine, and BASE+C showed a potent anti-inflammation on adjuvant arthritis. Any inhibitory actions on various inflammatory models by B and BASE+B (shosaiko-to) were not observed. None of BASE and additional prescriptions showed a protective action on heat-induced hemolysis of rat erythrocytes. Daisaiko-to and saikokeishi-to possess potent inhibitory actions on acute and chronic inflammation in rats.

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