Increased release of hydrogen peroxide and superoxide anion from asbestos-primed macrophages
- 1 June 1985
- journal article
- research article
- Published by Springer Nature in Inflammation
- Vol. 9 (2) , 139-147
- https://doi.org/10.1007/bf00917586
Abstract
The ability of asbestos-elicited murine peritoneal macrophages to release superoxide anion and hydrogen peroxide, followingin vitro triggering, has been investigated. The asbestos-elicited macrophages produced increased levels of super oxide and hydrogen peroxide compared to control macrophages and similar levels to those produced byCorynebacterium parvum elicited macrophages. The supernatants from asbestos-elicited macrophages which had been triggered invitro were capable of impairing the ability of α1protease inhibitor to inhibit elastase function. The catalase sensitivity of this effect showed it to be due to hydrogen peroxide.This publication has 16 references indexed in Scilit:
- Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophagesImmunology Letters, 1983
- The Pathogenesis of Asbestos-Associated DiseasesNew England Journal of Medicine, 1982
- Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages—Induction by multiple nonphagocytic stimuliCellular Immunology, 1981
- SECRETION OF SUPEROXIDE ANIONPublished by Elsevier ,1981
- A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in cultureJournal of Immunological Methods, 1980
- The Macrophage as an Effector CellNew England Journal of Medicine, 1980
- Oxygen Intermediates and the Microbicidal EventPublished by Springer Nature ,1980
- The role of macrophage activation in chronic inflammationInflammation Research, 1978
- The synthesis and analytical use of a highly sensitive and convenient substrate of elastaseBiochemical Medicine, 1974
- Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytesNature, 1974