Antibodies to Yersinia enterocolitica in Thyroid Disease

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Abstract
The prevalence of elevated antibody titers against Y. enterocolitica was studied in normal subjects, patients with a variety of nonthyroidal illnesses and patients with thyroid disease. In contrast to the low prevalence of antibodies in controls (< 8%), 48 of 67 patients (75%) with a variety of thyroid disorders had titers > 1:8. Antibodies were found in 24 of 36 patients with Graves'' disease, 5 of 6 with autonomous adenoma, 7 of 7 with Hashimoto''s thyroiditis, 3 of 5 with idiopathic primary hypothyroidism, 4 of 11 with nontoxic nodular goiter and 1 of 2 with thyroid carcinoma. Antibodies to serotype 3 were the most prevalent, occurred in the highest titers and were found particularly in patients with Graves'' disease. Despite the infrequent occurrence of Yersinia infection in the USA as compared with Scandinavia, patients with thyroid disorders have a higher prevalence of antibodies to Yersinia than normal subjects or patients with other disorders.

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