EFFECTS OF DIETARY LONG CHAIN PUFAs ON HIPPOCAMPAL LIPID PEROXIDATION AND NMDA RECEPTOR SUBUNITS A AND B CONCENTRATION IN STREPTOZOTOCIN-DIABETIC RATS
- 1 January 2004
- journal article
- research article
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 114 (10) , 1353-1364
- https://doi.org/10.1080/00207450490476147
Abstract
This study examined the effects of streptozotocin (STZ)diabetes and dietary long chain polyunsaturated fatty acids (LC-PUFAs) on hippocampal N-methyl-D-aspartate (NMDA) receptor subunit expression and lipid peroxidation. MDA level was significantly increased after 8 weeks of STZ-diabetes. LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats. Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats. Consequently, dietary LC-PUFAs can partially restore hippocampal NMDA receptors and decrease lipid peroxidation in diabetes. LC-PUFAs are thus a possible prophylactic means for preventing the cognitive deficiencies of diabetes.Keywords
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