THE DESOXYRIBOSE NUCLEIC ACID (DNA) CONTENT OF HUMAN MONOCYTES AND THEIR DERIVATIVES DURING GIANT CELL FORMATION IN VITRO

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Abstract
1. The desoxyribose nucleic acid (DNA) content of individual cell nuclei in monocytes and their derivatives, multinucleated giant cells, has been determined by microspectrophotometry. These measurements were performed on Feulgen stained material. 2. Although most of the measurements of individual nuclei in cultures incubated from 4 to 138 hours were close to diploid value, there were variations in some nuclei well above and below this value. 3. The data indicated that DNA was being synthesized during cultivation. 4. Amitosis occurred in some of the nuclei of the multinucleated giant cells after these cells had formed by cell fusion.