FATE OF ORALLY-ADMINISTERED ANTIBIOTIC SENSITIVE ESCHERICHIA-COLI IN THE INTESTINE OF THE NEWBORN

  • 1 January 1978
    • journal article
    • research article
    • Vol. B129  (4) , 581-596
Abstract
In an intensive care unit, 14 [human] newborns, without antibiotic intake, received orally 1 ml of culture broth from an antibiotic-sensitive strain of E. coli marked with resistance to sodium azide. The fate of the E. coli administered was studied to determine whether an interaction was obtained between that strain and antibiotic-resistant enterobacteria in the gut flora. In 3 infants the strain administered developed and was the only enterobacterium excreted during the 1st wk; in 4 others the strain was recovered during 1 wk or more in quantities > 106/g of stools. In 6 others, the strain appeared for less than 1 wk and/or in quantity less than 106/g of stools. In 1 child the strain could not be recovered at all. These data show what is obtained in holoxenic newborns in spite of challenge with many other bacteria. They were obtained with an ubiquitous E. coli and can be used as a control for further studies.

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