A Novel Nuclear Form of Estradiol Receptor in MCF-7 Human Breast Cancer Cells
- 14 September 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4667) , 1162-1165
- https://doi.org/10.1126/science.6474170
Abstract
Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.This publication has 17 references indexed in Scilit:
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