Vascular and Lymphatic Absorption of Radioactive Albumin from the Lungs

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Abstract
Plasma absorption studies were carried out on normal dogs and dogs with heart failure, with and without total lymph drainage from thoracic duct and right lymph ducts, after radioactive iodinated albumin (RISA) had been instilled into the lungs to explore a possible method for an indirect measurement of lung lymph flow. RISA entered plasma from the lungs mainly through the bloodstream. Its concentration in lung lymph correlated poorly with total lung lymph flow. More RISA entered the plasma than is normal in heart failure, implying an increased alveolar capillary permeability to protein in pulmonary oedema.