Effect of Neonatal Thymectomy on the Development of Ozone Tolerance in Mice

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Abstract
Male white Swiss mice, thymectomized at birth, were unable to develop tolerance to ozone when pre-exposed to sublethal concentrations of 0.3 and 5.0 ppm of ozone for one hour. On the other hand, tolerance was readily induced in sham-operated animals. Thus the thymus appears to be necessary during maturation for the development of tolerance to ozone. No statistical difference in mortality was shown between mice pre-exposed to 0.1 ppm of ozone and those not so pre-exposed, despite the fact that a larger number of pre-exposed animals survived compared to those not pre-exposed.