Isolated Rat Liver Needs Calcium to Make Bile

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Abstract
When normal rat livers were perfused with heparinized normal rat whole blood by the Brauer technique, between 10 and 15 .mu.l of bile were excreted per min. This amount was drastically reduced by the addition of sodium citrate to the blood. When calcium chloride was subsequently added, bile flow returned to normal if the interval between the additions of citrate and Ca was not over 1 h. Magnesium chloride had no such corrective effect. Two tests of liver function, generation of factor VII and conversion of [14C]alanine to TCA[trichloroacetic acid]-precipitable 14C, were unaffected by the addition of citrate to plasma-free perfusions.

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