Effect of Hemorrhage on Renal Handling of Sodium in Normal and Adrenalectomized Dogs

Publisher Website
Google Scholar
Abstract
Effects of hemorrhage and reinfusion of the blood were determined on glomerular filtration rate, plasma Na and amount of Na excreted in normal and in adrenalectomized dogs. Animals were anesthetized with sodium pentobarbital and urine was collected from each kidney by means of a catheter introduced through an incision in the ureter. It was found that hemorrhage of moderate degree in animals with adrenal glands causes a decrease in Na load and a greater percentage decrease in Na excretion. Typically, following reinfusion of the blood there is a rise in the Na load, related mainly or entirely to the recovery of GFR, while the Na excretion remains down or continues to decrease. When chronically adrenalectomized animals were bled, under the conditions of these experiments, and the blood was reinfused the Na load did not recover. Infusion of glucose solution appears to be a factor contributing to circulatory failure in the adrenalectomized animals. Unfavorable effect of glucose solutions may be related to the reduction in plasma Na and K which is observed. Normal animals differed from the adrenalectomized animals in that under some circumstances they excreted only negligible amounts of Na in the presence of a normal Na load. Adrenalectomized animals did not under any circumstances show a failure of Na excretion ex cept when the Na load was reduced. No evidence was obtained that the adrenalectomized animals could conserve Na by increased tubular reabsorption in the presence of a normal Na load.