PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis
Open Access
- 14 July 2008
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-6
- https://doi.org/10.1155/2008/546753
Abstract
PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in the regulation of lipid metabolism, energy balance, artherosclerosis and glucose control. Recent studies suggest that they play an important role in regulating inflammation. This review will focus on PPAR-𝛼 regulation of the immune response. We describe how PPAR-𝛼 regulates differentiation of T cells by transactivation and/or interaction with other transcription factors. Moreover, PPAR-𝛼 agonists have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in mice, suggesting that they could provide a therapy for human autoimmune diseases such as multiple sclerosis.Keywords
Funding Information
- Gilson Longenbaugh Foundation (NS047546, NS044250, RG-3427)
This publication has 41 references indexed in Scilit:
- Transcriptional Modulation of the Immune Response by Peroxisome Proliferator-Activated Receptor-α Agonists in Autoimmune DiseaseThe Journal of Immunology, 2009
- Gemfibrozil Ameliorates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Independent of Peroxisome Proliferator-Activated Receptor-αMolecular Pharmacology, 2007
- Peroxisome proliferator‐activated receptor‐α agonist fenofibrate regulates IL‐12 family cytokine expression in the CNS: relevance to multiple sclerosisJournal of Neurochemistry, 2007
- Fibrates upregulate TRB3 in lymphocytes independent of PPARα by augmenting CCAAT/enhancer-binding proteinβ (C/EBPβ) expressionMolecular Immunology, 2007
- Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunityThe Journal of Experimental Medicine, 2007
- A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γNature, 2005
- Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's DiseaseNew England Journal of Medicine, 2005
- Evidence That Peroxisome Proliferator-activated Receptor α Is Complexed with the 90-kDa Heat Shock Protein and the Hepatitis Virus B X-associated Protein 2Journal of Biological Chemistry, 2003
- Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosisNeurology, 1995
- The immunopathogenesis and regulation of T-cell-mediated demyelinating diseasesImmunology Today, 1994