A STUDY OF THE EFFECTS OF ISOTONIC SERUM AND SALINE INFUSION FOLLOWING TRAUMA IN DOGS

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Abstract
Anesthetized dogs were subjected to severe trauma. It was not possible to standardize the amt. of trauma. Circulating time, plasma vol., plasma proteins, plasma CO*, hematocrit were detd., and blood pressure was recorded before and after trauma. Saline solns. or isotonic serum was infused, when blood pressure had dropped to 50 mm Hg, and remained there for 10 min. or longer. Five saline infused dogs lived 145 min., one, 270 min. after infusion. The serum infused dogs lived 405 min. and longer. Saline raised blood pressure for short periods of time only, while serum maintained the elevated pressure for a long time. Saline left the circulation soon, together with plasma proteins (washing out effect), while serum elevated and maintained plasma proteins for prolonged periods of time. Plasma CO2 and circulating time were improved for short periods of time by saline, for prolonged periods of time by serum infusion. Infusion with serum, after saline had failed to restore the animal, was followed by marked improvement.