Induction of NO synthesis in macrophages by Newcastle disease virus is associated with activation of nuclear factor-κB

Open Access
Publisher Website
Google Scholar
Abstract
Newcastle disease virus (NDV) has received much attention recently because of its non-specific immune stimulating potential and its various anti-tumor activities. Here we describe that NDV induces synthesis of NO and causes an activation of nuclear factor-kB (NF-kB) In murine macrophages. These reactions were part of an activation process which included also stimulation of adenosine deaminase and inhibition of 5'-nucleotidase. NDV-mediated NO synthesis and NF-kB activation were blocked by an antioxidant (butylated hydroxyanisole), by an inhibitor of protein tyrosine kinase (genistein) and of protein kinase A (H-89), but not by an inhibitor of protein kinase C (staurosporin). These data suggest that signalling requirements of NF-kB activation and NO production in NDV-treated macrophages are similar.

This publication has 0 references indexed in Scilit: