Purine nucleosides XVII. The synthesis and conformation of 6‐amino‐9‐β‐D‐ribopyranosylpurine and related derivatives prepared via the fusion procedure
- 1 June 1967
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 4 (2) , 246-250
- https://doi.org/10.1002/jhet.5570040213
Abstract
The preparation of 2, 6‐dichloro‐9‐(2′,3′,4′‐tri‐O‐acetyl‐β‐D‐ribopyranosyl)purine (I) has been accomplished utilizing the acid catalyzed fusion procedure. The displacement of the 6‐chloro group, or the 2‐ and 6‐chloro group has been studied. Several new 6‐substituted‐9‐(β‐D‐ribopyranosyl)purines have been prepared by catalytic dehalogenation of the corresponding 2‐chloropurine nucleosides. The conformation and configuration of these D‐ribopyranosylpurines has been assigned with the assistance of proton magnetic resonance studies.Keywords
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