Generalized Connective Tissue Nevi and Ichthyosis in Down's Syndrome

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Abstract
The first description of a localized connective tissue nevus with a decreased amount of elastic tissue is credited to Lewandowsky in 1921. Various authors designated these localized hamartomas as nevus anelasticus according to the histologic presentation of the nevus. Sachs1 reported a generalized process that developed after furunculosis and Loewenthal2 described a case in which the lesions became generalized over a ten-year period. We report a case of generalized connective tissue nevi with a decrease in elastic tissue in a patient with Down's syndrome. Report of a Case A 47-year-old man who had Down's syndrome was admitted to Bronx Municipal Medical Center, New York, for treatment of sepsis. His family related a history of crops of boils that appeared approximately ten years ago. After draining a whitish material, there were residual nodules. Simultaneously, a "mossy appearance" of the skin occurred at the periphery of the nodules. There was no

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