Determination of vanilmandelic acid and homovanillic acid in urine by gas chromatography.

Abstract
Vanilmandelic acid and homovanillic acid in a small quantity of urine from a patient with neuroblastoma were purified by adsorption on Amberlite XAD-4, with 3-methoxy-4-hydroxyphenylethanol added as an internal standard, and converted to trifluoroacetyl-hexafluoroisopropyl derivatives. Their quantities were determined by the use of a gas chromatograph equipped with a 2% OV-17 column and an electron capture detector.

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