Cytotoxic and Antiplatelet Aggregation Principles from Aglaia elliptifolia
- 1 June 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (6) , 606-608
- https://doi.org/10.1021/np970163+
Abstract
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.Keywords
This publication has 3 references indexed in Scilit:
- Insecticidal 1H-cyclopentatetrahydro[b]benzofurans from Aglaia odorataPhytochemistry, 1993
- Cytotoxic Diterpenes from the Rhizomes ofHedychium coronariumPlanta Medica, 1988
- Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesivenessJournal of Clinical Pathology, 1962