Experimental infection of monkeys withLeptospira interrogansserovarhardjo

Abstract
SUMMARY: Grivet monkeys experimentally infected with two different strains ofLeptospira interrogansserovarhardjoshowed no signs of severe clinical disease. There were no significant macroscopic lesions in any of the tissues examined, but the organisms were demonstrated in various tissues by immunofluorescent technique and were isolated from the blood and urine of two monkeys and the kidney of one. Abraded skin was shown to be a viable route of infection in non-human primates.