Penicillamine and Collagen Metabolism
- 1 January 1979
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 8 (sup28) , 71-77
- https://doi.org/10.3109/03009747909108241
Abstract
Penicillamine blocks the crosslinking of collagen in man and in all the animal species it has been tested in. At the standard dose in which it is used it binds to the aldehydes present in collagen and prevents them from forming crosslinks. It is more efficient in inhibiting the crosslinking of soft tissues, where the aldehydes are derived from lysine, and less effective in preventing cross-linking of bone, where the aldehydes involved are primarily those derived from hydroxylysine. At very high doses it can inhibit lysyloxidase activity by making Cu unavailable to the enzyme.Keywords
This publication has 23 references indexed in Scilit:
- Effect of Low Dosage Schedule of D-Penicillamine on Collagen Cross-Linking in a Nine Week Immobilized Rabbit KneeConnective Tissue Research, 1977
- Metabolic pathways and control mechanisms involved in the biosynthesis and turnover of collagen in normal and pathological connective tissuesJournal of Oral Pathology & Medicine, 1973
- Characterization of the aldehydes present on the cyanogen bromide peptides from mature rat skin collagenBiochemistry, 1971
- Extraction of α and β components from insoluble collagen by thiol compoundsBiochemical and Biophysical Research Communications, 1966
- Accumulation of a collagen precursor in the skin of penicillamine-treated ratsBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- D-penicillamine, with particular relation to Wilson's diseaseJournal of Chronic Diseases, 1964
- An intermolecular defect of collagen in experimental lachyrismBiochimica et Biophysica Acta, 1963
- The reaction of thiol amino acids with pyridoxal 5′-phosphate in the absence and in the presence of l-glutamic acidBiochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1963
- Reaction of Pyridoxal-5-phosphate with AminothiolsJournal of the American Chemical Society, 1960
- ALTERATIONS IN STATE OF MOLECULAR AGGREGATION OF COLLAGEN INDUCED IN CHICK EMBRYOS BY ß-AMINOPROPIONITRILE (LATHYRUS FACTOR)The Journal of Experimental Medicine, 1959