Uptake of and response to norepinephrine by certain tissues of hypertensive rats

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Abstract
Rats were made hypertensive by 1 of the following techniques: "adrenal regeneration", figure-of-8 knot around 1 kidney, ingestion of a 10% NaCl solution. After 2 mo., the adrenal regeneration rats were hypertensive, and there was a significant decrease in the capacity of their hearts to take up NE [norepinephrine] and a significant increase in the inotropic response to the amine. Similar results were obtained with hearts and aortic strips of renal hypertensive rats and of rats made hypertensive by drinking a 10% NaCl solution. In renal hypertensive rats, there was no appreciable difference in the time of appearance of hypertension, the decrease in NE uptake by the heart or aorta, or the increase of the inotropic response. Previous work showing a decrease of NE uptake in rats made hypertensive by administration of deoxycorticosterone was confirmed utilizing 3 other models of the disease.

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