DEMONSTRATION OF HIGH AFFINITY HEXOSE UPTAKE IN CEREBRAL CORTEX SLICES

Abstract
Abstract— The high‐affinity glucose transport system (Km 0.2–0.4 mm), previously detected in synaptosome preparations, has now been demonstrated to be present in slices of the cerebral cortex incubated in vitro. The kinetic properties of this undirectional uptake process in slices were similar to those exhibited by synaptosomes. The results are discussed with respect to the possible sites of the high affinity and low affinity glucose transport processes in the brain.