CROSS REACTIONS BETWEEN HUMAN TRANSPLANTATION ANTIGENS AND BACTERIAL LIPOPOLYSACCHARIDES1

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Abstract
SUMMARY Certain deesterified lipoplysaccharides (DeLPS) from gram negative bacteria were shown to specifically inhibit the lymphocytotoxie activity of some of the 17 HL-A specificities tested. The DeLPS tested were derived from Escherichia coli of strains K-235, B-4, B-5, B-8, and from Salmonella typhimurium, Salmonella typhosa, and Salmonella enteritidis. Inhibition was not attributable to anticomplementary action of the bacterial substances or to the inhibitors coating the lymphocytes. The degree of inhibition specific for an HL-A group varied from serum to serum, thus revealing underlying heterogeneity of HL-A antisera. These data suggest that some lymphocytotoxins may be produced in response to bacterial infection, which then cross react with HL-A antigens of an allograft or of the host's own tissues.

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