Ventilatory Response of the Unrestrained and Unanesthetized Hamster to CO2

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Abstract
A method is presented for measuring ventilation of small animals without the use of anesthesia or any physical restraint. It consists of enclosing the animal in an airtight chamber and recording the pressure increase within the chamber resulting from the warming and wetting of the inspired tidal volume. Upon expiration the pressure falls. Knowing the absolute pressure change, air temperature, humidity of the inspired air and the chamber volume, the tidal volume can be calculated. Hamsters were exposed to a spectrum of CO2 concentrations (0-35%) in 20% O2 and N2- The ventilatory responses were recorded. Peak ventilation occurred when the inspired gas mixture contained about 20% CO2.

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