Urinary Protein Patterns in Patients with Uroepithelial Tumours: Effect of Surgery and Radiotherapy

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Abstract
Albumin, transferrin and immunoglobulins A, G and M were determined in serum and urine from 84 patients with uroepithelial tumors. There were 76 patients with bladder tumors, of which 19 previously received radiotherapy and 51 were untreated, whereas the remaining 6 required urinary diversion with nephrostomy or cutaneous ureterostomy because of ureteric tumor obstruction. Eight patients with tumors situated in the renal pelvis or ureter were examined. Seven of these 8 patients could be examined before and after surgical treatment. The changes in urinary protein patterns were compared with the results of various types of treatment of uroepithelial tumors. A significant reduction in urinary proteins was seen after successful treatment, or when the urinary flow was diverted so that it had no tumor contact.