Chlorpromazine Blockade of Water Imbibition by Frog Gastrocnemius

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Abstract
Chlorpromazine (1.6 x 10-3 [image]) produces marked in-hibition of water uptake by intact frog muscle shaken in distilled water. This block appears unrelated to antihistaminic, adrenergic blocking, or tranquilizing properties of the drug. Selected compounds exhibiting carbonic anhydrase inhibition, anticholinergic activity, analgetic and anti-inflammatory activity, adrenergic activity, monamine oxidase inhibition, cholinesterase inhibition, metabolic uncoupling and high energy phosphate supply produce little or no effect on water uptake. Correlation exists between block of water inbibition and loss of sodium and potassium from the muscle.