MORPHOMETRIC AND HISTOLOGICAL ANALYSIS OF LUNGS OF SYRIAN GOLDEN-HAMSTERS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 125  (MAR) , 527-553
Abstract
The Syrian golden hamster (Mesocricetus auratus) is a very popular species for lung carcinogenesis studies. Hamster morphometry and histology were studied to determine the differences between hamster and human lungs which may have relevance to lung carcinogenesis. Morphometric measurements were made on fresh lungs, lung casts and histological sections. Cell type and frequency measurements were determined from frozen 1 .mu.m plastic (glycol methacrylate) and EM sections. A standard terminology for hamster lung histology is established and differences between hamster and human lung morphometry and histology are discussed. Species'' differences relevant to lung carcinogenesis include lung anatomy, distribution and nature of mucous and serous secretions, distribution and type of epithelial cells and distribution of lymphoid tissue.

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