Abstract
At Bellevue Hospital in New York in 1953-54 a large majority of staphylococci (Micrococcus pyogenes var. aureus) isolated from patients were found to be of group III phage patterns resistant to penicillin, tetracyclines, and streptomycin. Fifty-five strains similarly obtained at a nearby hospital in the interval 1932-48 did not show these characteristics. It was found that newly hospitalized patients acquired these multiple drug resistant phage group strains most rapidly if they were treated with tetracyclines, less rapidly if treated with penicillin, and least rapidly if they received no antimicrobial treatment.