An Efficient and Practical Route to Enantiomerically Pure (+)-(1R,2R)- and (-)-(1S,2S)-1,2-Diphenylethane-1,2-diamines
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (11) , 1023-1024
- https://doi.org/10.1055/s-1990-27082
Abstract
The synthesis of the title compounds is easily achieved by the asymmetric Sharpless dihydroxylation of trans-stilbene to the corresponding enantiomerically pure diols. The conversion of the diols to the di-p-toluenesulfonates and subsequent reaction with sodium azide affords the diazides, which are reduced by lithium aluminum hydride to the optically pure 1,2-diamines.Keywords
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