Synthesis of 9,11-epoxy-9a-homoprostaglandin analogues
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 980-989
- https://doi.org/10.1039/p19780000980
Abstract
Starting from Diels–Alder adducts of furan with maleic anhydride, maleic acid, and dimethyl acetylenedicarboxylate, the synthesis of prostaglandin-H1(PGH1) analogues, in which the bicyclic part of PGH1 is replaced by the 7-oxabicyclo[2.2.1]heptane moiety, is described. Isomers with the two side-chains in exo,exo-, exo,endo-, and endo,exo-positions and their C(15)-epimers have been synthesised.This publication has 1 reference indexed in Scilit:
- Structure-activity relationships in a series of 11-deoxy prostaglandinsProstaglandins, 1976