Transfer of diclofenac sodium across excised guinea pig skin on high-frequency pulse iontophoresis. I. Equivalent circuit model.
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (4) , 1019-1021
- https://doi.org/10.1248/cpb.38.1019
Abstract
High frequency pulse iontophoresis of diclofenac sodium across excised guinea-pig skin was carried out in vitro. An equivalent circuit model was constructed to simulate the time coureses of voltage drop across the donor solution and the skin. Parameter values obtained by the least-squares adaptation of the model to observed data were consistent with expectation and validated the proposed model.This publication has 2 references indexed in Scilit:
- Enhanced percutaneous absorption via iontophoresis I. Evaluation of an in vitro system and transport of model compoundsInternational Journal of Pharmaceutics, 1986
- The Routine Fitting of Kinetic Data to ModelsBiophysical Journal, 1962