Hormonal Influences on the Growth and Progression of Cancer

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Abstract
THE inter-relation between the sex hormones and certain forms of cancer was first appreciated by Schinzinger1 in 1889, and demonstrated in man by Sir George Beatson,2 who carried out ovariectomy for carcinoma of the breast and obtained a remission of the disease. This work was soon confirmed by others,3 and by 1905, Lett4 was able to report a series of 99 cases of inoperable carcinoma of the breast treated by oöphorectomy. In this series he observed that a good clinical response occurred in 41 per cent of the patients younger than fifty years of age but in only 23 per . . .