AGGLUTININS TO RABBIT ERYTHROCYTES IN EXTRACTS OF HUMAN MALIGNANT TISSUES

Abstract
Agglutinins to rabbit erythrocytes in extracts from human malignant tissues were identified as the naturally occurring Ig[immunoglobulin]G antibodies in human serum to rabbit erythrocytes. This was revealed by agglutination, absorption, antiglobulin and inhibition tests, immunization of rabbits and immunochemical analyses. The agglutinins can be used as convenient markers for extracellular Ig and unspecifically bound Ig in tumor tissues. Apparently the extracts also contained small amounts of IgA antibodies to rabbit erythrocytes.

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