Synthesis of 8-methoxy-15,16-dinor-6,8,10-trichothecatriene 12,13.alpha.-epoxide and 12,13.beta.-epoxide as potential antineoplastic agents
- 1 January 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (1) , 96-97
- https://doi.org/10.1021/jm00175a021
Abstract
8-Methoxy-15,16-dinor-6,8,10-trichothecatriene 12,13.alpha.-epoxide (5) and 12,13.beta.-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of 13C NMR. The epoxide 5 was active against [human oral carcinoma] 9KB in vitro and [mouse leukemia] P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.This publication has 1 reference indexed in Scilit:
- Synthesis of 6,9-bisnormethyl-8-methoxy-12,13-epoxy-6,8,10-trichothecatrieneThe Journal of Organic Chemistry, 1977