In vivo Percutaneous Penetration of Corticoids in Man and Unresolved Problems in Their Efficacy

1 January 1976

journal article
Published by S. Karger AG in Dermatology

Vol. 152 (Suppl. 1) , 11-25
https://doi.org/10.1159/000257863

Abstract

This paper reviews the percutaneous penetration of corticosteroids in vivo in man utilizing urinary excretion of ¹⁴C-hydrocortisone as the experimental method. In general corticosteroids are only minimally absorbed from most areas of glabrous skin. Increasing the amount that penetrates – by use of occlusion – and increasing concentration provides the most practical method currently available for increasing efficacy in treatment-resistant dermatoses. Some practical research problems relevant to topical corticoid efficacy are discussed.

Keywords

HYDROCORTISONE
VEHICLES
PHARMACOKINETICS

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