SAFE REVERSAL (1): ATROPINE FOLLOWED BY NEOSTIGMINE
Open Access
- 1 January 1968
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 40 (1) , 27-29
- https://doi.org/10.1093/bja/40.1.27
Abstract
An electrocardiographic investigation was carried out in ten healthy adult patients anaesthetized using thiopentone, nitrous oxide and oxygen with tubocurarine. The arterial carbon dioxide tension was raised by adding 2.5 per cent carbon dioxide to the fresh gas flow whilst intermittent positive pressure ventilation was maintained throughout the whole period of anaesthesia and reversal. The Pco2 varied between 45 and 90 mm Hg and the pH values varied between 7.12 and 7.30. The intravenous injection of atropine 1.2 mg followed after 2 minutes by neostigmine 2.5 mg did not produce any serious cardiac arrhythmia provided adequate oxygenation was ensured throughout the whole period of reversal.Keywords
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