Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease
Open Access
- 21 April 1999
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 281 (15) , 1401-1406
- https://doi.org/10.1001/jama.281.15.1401
Abstract
A central tenet of Alzheimer disease (AD), established 20 years ago and repeatedly replicated, is the loss of cortical cholinergic markers, specifically, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity, in postmortem tissue from AD patients.1-3 This abnormality has been shown to correlate with neuropathological markers4 and with the severity of dementia.4,5 Therapies designed to reverse the cholinergic deficit, such as AChE inhibitors, are in large measure based on the importance of the cholinergic deficit to cognition and the symptoms of AD.6-8Keywords
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