Inconsistency of Synergy Between the β -Lactamase Inhibitor CP-45,899 and β -Lactam Antibiotics Against Multiply Drug-Resistant Enterobacteriaceae and Pseudomonas Species
Open Access
- 1 February 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 19 (2) , 361-363
- https://doi.org/10.1128/aac.19.2.361
Abstract
Synergy between CP-45,899 and ampicillin or newer β -lactam antibiotics against multiply drug-resistant Enterobacteriaceae and Pseudomonas species was inconsistent. In contrast, synergy between CP-45,899 and ampicillin against β -lactamase-producing strains of Haemophilus influenzae type b and Bacteroides fragilis was consistent and marked.This publication has 12 references indexed in Scilit:
- In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strainsAntimicrobial Agents and Chemotherapy, 1980
- Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporinsAntimicrobial Agents and Chemotherapy, 1980
- CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and BacteroidesAntimicrobial Agents and Chemotherapy, 1980
- In Vitro Activity of LY127935Antimicrobial Agents and Chemotherapy, 1979
- Factors Contributing to Resistance to Beta-Lactam Antibiotics in Bacteroides fragilisAntimicrobial Agents and Chemotherapy, 1979
- Comparative Inhibition of β-Lactamases by Novel β-Lactam CompoundsAntimicrobial Agents and Chemotherapy, 1979
- CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological CharacterizationAntimicrobial Agents and Chemotherapy, 1978
- A sulfone .BETA.-lactam compound which acts as a .BETA.-lactamase inhibitor.The Journal of Antibiotics, 1978
- The β-lactamases of Gram-negative bacteria and their rôle in resistance to β-lactam antibioticsJournal of Antimicrobial Chemotherapy, 1976
- Interaction of Clindamycin and Gentamicin In VitroAntimicrobial Agents and Chemotherapy, 1974